Model fitted: LME or GEE model
log(hormones) ~ Study + GA at sampling + Study:GA at sampling LME only: Random intercepts for Study ID and Plate GEE only: Independence correlation structure
38.2.1 Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
2.473411
1
0.1
ns
Study
1.757843
1
0.2
ns
GA_samp
8.736573
1
0.003
**
Study:GA_samp
1.550230
1
0.2
ns
hPL (μg/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
11.118300
1
0.0009
***
Study
5.570424
1
0.02
*
GA_samp
33.105635
1
<0.0001
***
Study:GA_samp
7.350297
1
0.007
**
GH2 (ng/ml)
Chisq
Df
Pr(>Chisq)
(Intercept)
1.122593
1
0.3
ns
Study
5.234170
1
0.02
*
GA_samp
8.992223
1
0.003
**
Study:GA_samp
5.263896
1
0.02
*
Insulin (uU/ml)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
0.395
0.395
0.5
ns
3
GA_samp
1
Inf
1.567
1.567
0.2
ns
2
Study:GA_samp
1
Inf
0.731
0.731
0.4
ns
HOMA-IR
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
0.298
0.298
0.6
ns
3
GA_samp
1
Inf
1.230
1.230
0.3
ns
2
Study:GA_samp
1
Inf
0.765
0.765
0.4
ns
Glucose (mmol/L)
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
0.006
0.006
0.9
ns
3
GA_samp
1
Inf
0.003
0.003
1.0
ns
2
Study:GA_samp
1
Inf
0.086
0.086
0.8
ns
38.2.2 Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
Var
Effect
P
(Intercept)
1.64 (-0.41, 3.67)
0.12
StudySTOP
1.46 (-0.69, 3.61)
0.19
GA_samp
0.20 (0.07, 0.33)
0.004
StudySTOP:GA_samp
-0.09 (-0.24, 0.05)
0.21
hPL (μg/ml)
Var
Effect
P
(Intercept)
1.82 (0.67, 2.96)
0.001
StudySTOP
-1.38 (-2.58, -0.17)
0.02
GA_samp
0.21 (0.13, 0.28)
<0.0001
StudySTOP:GA_samp
0.11 (0.03, 0.19)
0.008
GH2 (ng/ml)
Var
Effect
P
(Intercept)
-0.69 (-2.09, 0.78)
0.30
StudySTOP
-1.61 (-3.17, -0.09)
0.03
GA_samp
0.13 (0.03, 0.22)
0.006
StudySTOP:GA_samp
0.11 (0.01, 0.21)
0.03
Insulin (uU/ml)
Var
Effect
P
(Intercept)
1.37 (-2.34, 5.08)
0.47
StudySTOP
1.23 (-2.61, 5.07)
0.53
GA_samp
0.14 (-0.10, 0.38)
0.26
StudySTOP:GA_samp
-0.11 (-0.37, 0.14)
0.39
HOMA-IR
Var
Effect
P
(Intercept)
0.11 (-3.61, 3.83)
0.95
StudySTOP
1.08 (-2.79, 4.95)
0.58
GA_samp
0.13 (-0.11, 0.37)
0.29
StudySTOP:GA_samp
-0.12 (-0.38, 0.14)
0.38
Glucose (mmol/L)
Var
Effect
P
(Intercept)
1.71 (0.58, 2.85)
0.003
StudySTOP
-0.04 (-1.19, 1.10)
0.94
GA_samp
0.00 (-0.07, 0.08)
0.90
StudySTOP:GA_samp
-0.01 (-0.09, 0.07)
0.77
38.2.3 Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
38.2.4 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
37.84059
14.97325
183.71665
17.33445
82.60489
STOP
10
64.25777
10.79816
25.61462
45.47803
90.79244
SCOPE
16
125.40320
24.78532
46.73448
84.25636
186.64422
STOP
16
122.20695
26.05851
61.88348
79.79445
187.16261
hPL (μg/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
48.12118
9.400344
116.3177
32.68197
70.85399
STOP
10
35.67218
1.710800
43.9918
32.38566
39.29222
SCOPE
16
165.09165
11.552861
112.4283
143.71802
189.64396
STOP
16
234.19079
20.961034
179.3138
196.27551
279.43032
GH2 (ng/ml)
Study
GA_samp
response
SE
df
lower.CL
upper.CL
SCOPE
10
1.764828
0.4232374
27.87312
1.0797268
2.884636
STOP
10
1.052072
0.0640941
50.34783
0.9309196
1.188992
SCOPE
16
3.744028
0.3480694
126.03402
3.1148611
4.500281
STOP
16
4.304273
0.5007060
185.72738
3.4216229
5.414615
Insulin (uU/ml)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
15.42851
10.443696
Inf
4.09391
58.14466
STOP
10
17.37172
1.623285
Inf
14.46449
20.86328
SCOPE
16
35.06535
5.621541
Inf
25.61042
48.01086
STOP
16
20.27501
4.212605
Inf
13.49286
30.46618
HOMA-IR
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
4.151566
2.7843932
Inf
1.115126
15.456106
STOP
10
3.826518
0.3878844
Inf
3.137036
4.667538
SCOPE
16
9.138816
1.7090499
Inf
6.334418
13.184787
STOP
16
4.200316
0.9587402
Inf
2.685292
6.570106
Glucose (mmol/L)
Study
GA_samp
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
10
5.833361
1.0212224
Inf
4.139067
8.221199
STOP
10
4.947693
0.0651983
Inf
4.821543
5.077144
SCOPE
16
6.006065
0.4569785
Inf
5.173987
6.971957
STOP
16
4.740833
0.1711949
Inf
4.416896
5.088528
38.2.5 Comparisons
Hormone
Contrast
GA_samp
Ratio of Geometric means (95% CI)
P-value
PRL (ng/ml)
STOP / SCOPE
10
1.70 (0.81, 3.58)
0.2
PRL (ng/ml)
STOP / SCOPE
16
0.97 (0.67, 1.42)
0.9
hPL (μg/ml)
STOP / SCOPE
10
0.74 (0.50, 1.10)
0.1
hPL (μg/ml)
STOP / SCOPE
16
1.42 (1.15, 1.75)
0.001
GH2 (ng/ml)
STOP / SCOPE
10
0.60 (0.36, 0.99)
0.05
GH2 (ng/ml)
STOP / SCOPE
16
1.15 (0.87, 1.51)
0.3
Insulin (uU/ml)
STOP / SCOPE
10
1.13 (0.30, 4.30)
0.9
Insulin (uU/ml)
STOP / SCOPE
16
0.58 (0.35, 0.97)
0.04
HOMA-IR
STOP / SCOPE
10
0.92 (0.24, 3.48)
0.9
HOMA-IR
STOP / SCOPE
16
0.46 (0.26, 0.82)
0.008
Glucose (mmol/L)
STOP / SCOPE
10
0.85 (0.60, 1.20)
0.3
Glucose (mmol/L)
STOP / SCOPE
16
0.79 (0.67, 0.93)
0.005
38.2.6 Barplots by Study
Barplots in this section may be misleading due to involvement of Study by GA interaction.